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 Formulary Chapter 24: Children's Hospital Formulary - Full Chapter
Notes:

 Details...
24.16  Expand sub section  Neonatal Formulary
 note 


Abidec (Neonatal)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
For all pre-term infants < 34 weeks gestation and/or <1500g birth weight.

Dose: 0.6ml once daily (unlicensed dose)

Commence when tolerated milk feed (formula or breast) ≥ 165ml/kg/day.

Continue up to 6-12 months of age depending on diet.

Dalivit® is available when there are supply problems with Abidec, however the dose is 0.3ml daily due to the higher vitamin A content. 
   
Aciclovir (Neonatal)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
Link  IV dose and administration: prescribing and administration monograph
Link  Yorkshire & Humber Neonatal Network Monograph
   
Adrenaline  (Neonatal)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
Link  Yorkshire & Humber Neonatal Network Monograph
   
Alprostadil (Neonatal)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
500microgram/ml injection 
Link  Yorkshire & Humber Neonatal Network Monograph
   
Amoxicillin (Neonatal)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
Link  IV dose and administration: prescribing and administration monograph
   
Atracurium (Neonatal)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
Link  Yorkshire & Humber Neonatal Network Monograph
   
Atropine (Neonatal)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
Link  Neonatal intubation dosing guide - atropine
   
BCG vaccination (Neonatal)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
Benzylpenicillin (Neonatal)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
Link  IV dose and administration: prescribing and administration monograph
Link  Neonatal sepsis guideline (with meningitis)
Link  Yorkshire & Humber Neonatal Network Monograph
   
Blood Products (Neonatal)
View SPC online View childrens BNF  Track Changes
Formulary
Red
  • Not pharmacy products - order from Blood Bank 
  •    
    Caffeine citrate (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Carobel (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
       
    Cefotaxime (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Restricted Drug Restricted
    Red
  • Cefotaxime for any indication requires microbiology approval, including patients transferred to the unit where cefotaxime has already been initiated 
  • Link  IV dose and administration: prescribing and administration monograph
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Ceftazidime (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Cefuroxime (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Chloramphenicol (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
       
    Chlorothiazide (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
     
       
    Clarithromycin (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Co-amoxiclav (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
  • Oral dosing for chest infections in neonates without IV access (providing there have been no previous resistant gram negative bacteria isolated): dose as per BNFc (click icon to the left). When prescribed ensure the concentration (125/31) is clearly written on the prescription.
  • IV dosing on the recommendation of microbiology only: dose as per BNFc (click icon to the left), administration as per Paediatric Medusa IV Guide (see link below) 
  • Link  Paediatric Medusa IV Guide
       
    Colecalciferol (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
    3000units/ml oral solution (unlicensed) 
       
    Cyclopentolate 0.5% eye drops (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Dexamethasone (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Diphtheria, Tetanus, Pertussis (Acellular, Component), Poliomyelitis (Inactivated) and Haemophilus Type b Conjugate Vaccine (Adsorbed), Hepatitis B (Infanrix Hexa®) (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
    Link  Immunisation schedule - Public Health England
       
    Dobutamine (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Dopamine (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Elfin Trial (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Erythromycin (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
  • Oral dose and administration (GORD): BNF-c 
  •    
    Controlled Drug Fentanyl (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
    10microgram/ml injection (unlicensed) 
    Link  Neonatal intubation dosing guide - fentanyl
       
    Flucloxacillin (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  IV dose and administration: prescribing and administration monograph
       
    Fluconazole (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Fluids intravenous (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
  • 'Standard' solutions containing calcium are no longer used  
  •    
    Flumazenil (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Folic acid (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
    2.5mg/5ml liquid 
       
    Furosemide (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
     
       
    Gentamicin (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  IV dose and administration: prescribing and administration monograph
    Link  Neonatal sepsis guideline (with meningitis)
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Heparinised saline (Neonatal)
    View SPC online  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Hepatitis B vaccine and immunoglobulin (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
  • Dose: BNF-c 
  •    
    Hydrocortisone (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Ibuprofen (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Immunisations (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
    Link  Immunisation schedule - Public Health England
       
    Immunoglobulins (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
  • To request immunoglobulin, a clinician request form (see link below) needs to be completed before discussion with pharmacy 
  • Link  IVIg request form
       
    Insulin (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
    50units in 50ml pre-filled syringe 
       
    Isoniazid (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
  • For treatment of congenital tuberculosis see BNFc 
  •    
    Lidocaine (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
  • Infiltration anaesthesia: BNFc 
  •    
    Meningococcal group C conjugate vaccine (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
    primary immunisation schedule 
       
    Meropenem (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Metanium (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
       
    Metronidazole (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  IV dose and administration: prescribing and administration monograph
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Miconazole oral gel / topical cream (Daktarin®) (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
       
    Controlled Drug Midazolam (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Controlled Drug Morphine sulphate (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph - Neonatal Abstinence Syndrome (NAS)
    Link  Yorkshire & Humber Neonatal Network Monograph - pain, sedation
       
    Naloxone (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Noradrenaline (Neonatal)
    View adult BNF View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Nutriprem 2 (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
       
    Nystatin (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
    Oral liquid
    Topical cream discontinued 
       
    Octenisan (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
  • Use daily as a wash from 28 weeks of age 
  •    
    Omeprazole (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
     
       
    Palivizumab (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
    High Cost Medicine
  • Restricted to use for RSV prophylaxis in patients who meet the Yorkshire and Humber Specialised Commissioning Group criteria 
  •    
    Pancuronium (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Paracetamol (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
       
    Controlled Drug Phenobarbital (Phenobarbitone) (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Phenylephrine 2.5% minims (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Phenytoin (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Pneumococcal vaccine (Prevenar13) (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
    Link  Immunisation schedule - Public Health England
       
    Poractant alfa (Curosurf) (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
    High Cost Medicine
     
       
    Proxymetacaine 0.5% eye drops (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Ranitidine (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
     
       
    Rotavirus vaccine (Rotarix) (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
    Link  Immunisation schedule - Public Health England
       
    Salbutamol (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
  • For the management of hyperkalaemia. If IV route is unavailable, follow guidance in BNFc. 
  •    
    Sodium bicarbonate (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Yorkshire & Humber Neonatal Network Monograph
       
    Sodium chloride (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
  • Oral product used at HDFT is sodium chloride 1mmol/1mL 200mL (unlicensed medicine) 
  •    
    Sodium Phosphate (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
    Joulies phosphate solution (unlicensed medicine) 
       
    Spironolactone (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Suxamethonium (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
    Link  Neonatal intubation dosing guide - suxamethonium
       
    Syrup BP (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
    Unlicensed
    For cannulation 
       
    Sytron (Sodium feredetate) (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
    For all breast milk fed babies, particularly if:
    1. Weight <1500g
    2. <34 weeks gestation
    3. IUGR

    Consider iron supplementation in mixed fed infants if they are fed more breast milk than formula.

    Commence at 28 days of age.
    Continue up to 6-12 months of age depending on diet.

    Dose: 1ml per day or 0.5ml per day if mixed fed.

    Note: ESPGHAN recommends a dose of 2-3mg/kg/day. Iron supplementation may be started at 2-6 weeks of postnatal age. Anaemia of prematurity is not iron deficiency. 
       
    Tetracaine (Ametop®) (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Thick and Easy (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Amber
     
       
    Trimethoprim (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
       
    Vaccines - primary immunisation course (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Green
     
    Link  Immunisation schedule - Public Health England
       
    Vancomycin (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Vitamin K (phytomenadione) (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
     
       
    Zidovudine (Neonatal)
    View SPC online View childrens BNF  Track Changes
    Formulary
    Red
  • Follow BHIVA guidelines 
  •    
     ....
     Non Formulary Items
    Dalivit  (Neonatal)

    View adult BNF View SPC online View childrens BNF Track Changes
    Non Formulary
    Red
     
    Dinoprostone (Prostaglandin E2)  (Neonatal)

    View SPC online View childrens BNF Track Changes
    Non Formulary
    Red
  • Dinoprostone not licensed for this indication - use alprostadil
  •  
    Diphtheria, Tetanus, Pertussis (Acellular, Component), Poliomyelitis (Inactivated) and Haemophilus Type b Conjugate Vaccine (Adsorbed) (Pediacel®)  (Neonatal)
    (Changed to Infanrix Hexa)

    View SPC online View childrens BNF Track Changes
    Non Formulary
    Green
    Link  Immunisation schedule - Public Health England
     
    Indometacin  (Neonatal)

    View SPC online View childrens BNF Track Changes
    Non Formulary
    Red
  • 2014: product discontinued by manufacturer - consider ibuprofen as an alternative agent
  •  
    Sucrose 24%  (Neonatal)

    View SPC online View childrens BNF Track Changes
    Non Formulary
    Red
    Now using Syrup BP
     
      
    Key
    note Notes
    Section Title Section Title (top level)
    Section Title Section Title (sub level)
    First Choice Item First Choice item
    Non Formulary Item Non Formulary section
    Restricted Drug
    Restricted Drug
    Unlicensed Drug
    Unlicensed
    Track Changes
    Display tracking information
    click to search medicines.org.uk
    Link to adult BNF
    click to search medicines.org.uk
    Link to children's BNF
    click to search medicines.org.uk
    Link to SPCs
    SMC
    Scottish Medicines Consortium
    Cytotoxic Drug
    Cytotoxic Drug
    CD
    Controlled Drug
    High Cost Medicine
    High Cost Medicine
    Cancer Drugs Fund
    Cancer Drugs Fund
    NHSE
    NHS England
    Homecare
    Homecare
    CCG
    CCG

    Traffic Light Status Information

    Status Description

    Amber

    Medicines which are suitable to be prescribed in primary care only after specialist recommendation. Ongoing prescribing by primary care includes titration of dose and assessment of efficacy. There is no need for ongoing monitoring other than for general adverse effects as listed in the BNF & SPC.  

    Amber Shared Care

    Medicines which are suitable to be prescribed in primary care only after specialist recommendation only under a shared care protocol once the patient has been stabilised. Prior agreement must be obtained by the specialist from the primary care provider before prescribing responsibility is transferred. The shared care protocol must be approved by the Harrogate & Rurual District Area Prescribing Committee (HaRD APC).   

    Black

    Medicines which the Harrogate & Rural District Area Prescribing Committee (HaRD APC) has reviewed and does not recommend for use at present based on a review of clinical and/or cost effectiveness data.   

    Green

    Medicines suitable for routine use and can be prescribed within primary care within their licensed indication in accordance with nationally recognised formularies e.g. BNF, BNF for Children, Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing.  

    Grey

    Medicines which the Harrogate & Rural District Area Prescribing Committee (HaRD APC) have not yet reviewed.   

    Red

    Medicines for hospital use only. The responsibility for initiation and monitoring treatment should rest with an appropriate hospital clinician. The drug should be supplied by the hospital for the duration of the treatment course. Primary care prescriber initiation or continuation of treatemnt is not recommended.  

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